Home > Facts > Ephedra  

More About:

ephedra

Ergogenic Aids
(7% Match)

...ephedra, and caffeine. Anabolic Agents The most
Slim4Life
(3% Match)

...ephedra. On April 12, 2004 the FDA banned the sale
Sports Nutrition
(3% Match)

...ephedra, an herb sometimes called by its Chinese n
Dietary Supplements
(3% Match)

...ephedra, a weight-loss supplement that was later b
Ergogenic aids
(1% Match)

...ephedra sinica and sida cordifolia contain ephedri
Herbalife
(1% Match)

...ephedra-contained supplements beginning on April 1
Arthritis diet
(1% Match)

...ephedra, cinnamon, aconite, and coix. A combinatio
Sports Nutrition
(1% Match)

...ephedra, which can have adverse effects such as ne


Highlight any text in the article to look up more information!

Ephedra

Definition

Ephedra is a genus of plants found worldwide. One species, Ephedra sinica or Chinese ephedra, has a long history of use in complementary and alternative medicine (CAM). In the late twentieth century, ephedra gained popularity as a weight-loss supplement. The herb can cause life-threatening side effects, and since April 2004, sale of products containing ephedra have been banned in the United States. In Traditional Chinese Medicine (TCM) ephedra is called ma huang.

Purpose

Ephedra (ma huang) has been used in TCM for about 5,000 years primarily to treat sneezing, runny nose, coughing and other symptoms of a cold,

influenza, bronchitis, and allergy. In the 1990s ephedra was marketed in the United States as a dietary supplement that stimulated weight loss. It was also marketed to adolescents as a mood-altering “herbal Ecstacy” and to athletes to improve performance. In 2005 use of ephedra-containing supplements in the United States was banned.

Description

Ephedra is an evergreen plant with tiny leaves that grows to a height of about 12 in (30 cm). Many species of ephedra are found worldwide, but E. sinica used in herbal medicine grows mainly in dry, rocky areas of Mongolia and northern China. The stems and roots of the plant are used medicinally. Many other species of ephedra, for example, E. nevadensis or Mormon tea that grows in the western United States, do not have the same active ingredients as E. sinica

The active ingredients in ephedra are the alkaloids ephedrine and pseudoephedrine. These chemicals have effects similar to amphetamines. They stimulate the central nervous system and affect the heart and circulatory system. Ephedra causes blood vessels to narrow, increases heart rate, and raises blood pressure. These effects are enhanced when ephedra is taken with caffeine. Ephedra also expands the airways, making breathing easier. Researchers generally agree that ephedra is effective in treating cold and allergy symptoms

Standardized amounts of manufactured ephedrine and pseudoephedrine, the active ingredients found in ephedra, are used in many cold and allergy products made by traditional pharmaceutical companies and approved for sale by the FDA. For years, these drugs were sold in the United States over the counter without restrictions. Beginning in the early 2000s, a movement developed to limit access to these drugs by placing them behind the counter at the pharmacy, limiting the amount an individual could buy, and requiring identification to purchase the drugs. This came about more because ephedrine and pseudoephedrine are used in the manufacture of illicit methamphetamines (e.g., crystal meth) than because of safety concerns about the drugs

Ephedrine and pseudoephedrine are also effective appetite suppressants, especially when combined with caffeine. Many people who took diet pills containing ephedra or a combination of ephedra and caffeine did lose weight. However, they also experienced an increased risk of dangerous, sometimes fatal, side effects. Ephedra was brought to the attention of the FDAin the mid-1990sby alarge increase inthe number of reports from poison control centers and health care providers about serious adverse effects related to ephedra-containing weight-loss supplements. These side effects included dangerously high blood pressure, fast heart rate, stoke, and heart attack. By 2003, at least 155 deaths were linked to ephedra use, including that of Baltimore Oriole’s pitching prospect Steve Belcher. That same year, an analysis of side effects related to herbal therapy published in the Annals of Internal Medicine found that ephedra accounted for less than 1% of all herbal supplement sales, but was responsible for 64% of all reported negative events caused by herbs.

Ephedra and the Law

The FDA regulates ephedra and other dietary supplements under the 1994 Dietary Supplement Health and Education Act (DSHEA). At the time the act was passed, legislators felt that because many dietary supplements come from natural sources such as plants and because they have been used for hundreds of years by practitioners of CAM, these products did not need to be regulated as rigorously as prescription and over-the-counter drugs used in conventional medicine. The legislators decided that dietary supplements should be regulated the same way food is regulated. As a result, manufacturers of ephedra supplements, just like the manufacturers of cheese or cereal, did not have to prove that ephedra was either safe or effective before it could be sold to the public. They also were not required to tell the public about possible side

KEY TERMS

Alternative medicine—A system of healing that rejects conventional, pharmaceutical-based medicine and replaces it with the use of dietary supplements and therapies such as herbs, vitamins, minerals, massage, and cleansing diets. Alternative medicine includes well-established treatment systems such as homeopathy, traditional Chinese medicine, and Ayurvedic medicine, as well as more-recent, fad-driven treatments

Amphetamine—A drug that stimulates the central nervous system and can be physically and psychologically addictive

Complementary medicine—Includes many of the same treatments used in alternative medicine, but uses them to supplement conventional drug and therapy treatments, rather than to replace conventional medicine

Conventional medicine—Mainstream or Western pharmaceutical-based medicine practiced by medical doctors, doctors of osteopathy, and other licensed health care professionals

Dietary supplement—A product such as a vitamin, mineral, herb, amino acid, or enzyme, that is intended to be consumed in addition to an individual’s diet with the expectation that it will improve health

Traditional Chinese Medicine (TCM)—An ancient system of medicine based on maintaining a balance in vital energy or qi that controls emotions, spiritual, and physical well being. Diseases and disorders result from imbalances in qi, and treatments such as massage, exercise, acupuncture, nutritional and herbal therapy are designed to restore balance and harmony to the body.

effects of the herb. (Conventional pharmaceuticals must include potential side effects in their packaging.)

With ephedra and all other dietary supplements, the burden of proof falls on the FDA to show that the supplement is either unsafe or ineffective before the supplement can be restricted or banned. Information about a supplement’s safety and effectiveness is normally gathered only after people using the product develop health problems or complain that the product does not work

The FDA involvement with ephedra in weight-loss supplements began in 1996 after receiving more than 800 reports of adverse events in people taking products containing ephedra. In 1997 the FDA proposed regulating ephedra by requiring that the product carry a warning on the label stating that adults should take no more than 8 mg of ephedra at one time and no more than 24 mg in one day. The proposed regulation was fought by the diet supplement industry. During the course of public comment about the regulation, it became clear that there was little or no standardization of ephedra content among products or even within different batches of product from the same manufacturer. This lack of standardization made it difficult for consumers to know and control how much ephedra they were taking from day to day

In 2002, the FDA commissioned and independent organization to study ephedra-related complications and deaths. As a result of this study, the FDA banned the uncontrolled sale of dietary supplements containing ephedra based on the what the FDA called an “unreasonable risk of illness or injury.” The ban took effect on April 14, 2005

Several supplement makers have challenged the ban on ephedra containing supplements in federal and state courts. They argue that the FDA did not test supplements containing low doses of ephedra for safety and effectiveness and that a total ban on ephe-dra supplements based only on high-dose products was illegal. The FDA took the position that it was unethical to do more human testing of ephedra given the findings that ephedra-containing supplements increase the risk of stroke, heart attack, irregular heart beat, and similar serious cardiovascular events. On October 18, 2006, after several legal challenges, the United States Court of Appeals Tenth Circuit upheld the FDA ban on all ephedra-containing supplements regardless of dose. Nutraceutical Corporation, the plaintiff in the case, vowed to file another a petition for review with the United States Supreme Court

The ban on ephedra-containing supplements continues to be controversial. There is general agreement that ephedra does treat cold symptoms and does help people with short-term weight loss. However, these benefits do not, in the opinion of FDA scientists, outweigh the health risks associated with the ephedra-containing products. Ephedra continues to be legal in countries such as Germany, Japan, India, and China where it is widely used. Ephedra-containing supplements are easily available over the Internet, and it is estimated that several million Americans continue to use them.

Interactions

Studies have shown that ephedra interacts with many drugs used in conventional medicine, especially those used to treat heart problems and monoamine oxidase inhibitors (MAOI) used to treat mental depression, anxiety, and phobias.

Complications

At low doses, adverse side effects include headache, restlessness, anxiety, sleeplessness, nausea, difficulty urinating, and racing heart. At high doses, adverse reactions include sweating, enlarged pupils, fever, spasms, and death, usually through heart failure or stroke.

Parental concerns

Ephedra is a dangerous herbal supplement and should not be given to children. Accidental use of ephedra by children can result in serious side effects. In the case of accidental poisoning in the United States, call the national poisoning hotline at 1-800-222-1222, the local hospital emergency room, or emergency services.

BOOKS

Fillon, Mike. Ephedra Fact and Fiction: How Politics, the Press and Special Interests are Targeting Your Rights to Vitamins, Minerals, and Herbs. Orem, UT: Woodland Pub., 2004

PDR for Herbal Medicines, 3rd ed. Montvale, NJ: Thompson Healthcare, 2004

Pierce, Andrea. The American Pharmaceutical Association Practical Guide to Natural Medicines New York: William Morrow, 1999.

PERIODICALS

Bent, S., et al. “The Relative Safety of Ephedra Compared With Other Herbal Products.” Annals of Internal Medicine 138, no. 6 (March 18, 2003): 468-71

Harrison, Todd. “Ephedra: The Real Story.(INDUSTRY NEWS).” Nutraceuticals World 9, no. 9 (2006): 24-25

Shekell, P., S. Morton, M. Maglione, et al. “Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects.” Evidence Report/Technology Assessment No. 76 AHRQ Publication no. 03-E022, (February 2003).

ORGANIZATIONS

Alternative Medicine Foundation. P.O. Box 60016, Potomac, MD 20859. Telephone: (301) 340-1960. Fax: (301) 340-1936. Website: <http://www.amfoundation.org>

National Center for Complementary and Alternative Medicine Clearinghouse. P.O. Box 7923, Gathersburg, MD 20898. Telephone: (888) 644-6226. TTY: (866) 464-3615. Fax: (866) 464-3616. Website: <http://nccam.nih.gov>

Natural Standard. 245 First Street, 18th Floor, Cambridge, MA 02142. Telephone: (617) 444-8629. Fax: (617) 444-8642. Website: <http://www.naturalstandards.com>

Office of Dietary Supplements, National Institutes of

Health. 6100 Executive Blvd., Room 3B01, MSC 7517, Bethesda, MD 20892-7517 Telephone: (301)435-2920. Fax: (301)480-1845. Website: <http://dietary-supplements.info.nih.gov>.

OTHER

“Ma Huang.” Drugs.com February 13, 2004. [cited May 3, 2007]. <http://www.drugs.com/mtm/ma_huang.html>

Mayo Clinic Staff. “Ephedra (Ephedra sinica)/Ma Huang.” MayoClinic.com [cited May 3, 2007]. < http://www.mayoclinic.com/health/ephedra/NS_patient-ephedra>

Medline Plus. “Ephedra (Ephedra sinica).” U.S. National Library of Medicine, December 1, 2006. [cited May 3, 2007]. <http://www.nlm.nih/gov/medlineplus/druginfo/natural/patient-ephedra.html>

“Ephedra Consumer Advisory.” National Center for Complementary and Alternative Medicine. October 2004. [cited May 3, 2007]. <http://nccam.nih.gov/health/alerts/ephedra/consumeradvisory.htm>

Tish Davidson, A.M.


ADVERTISEMENT


Popular Web Searches:


McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams